Extrusion Operator, Sr. jobs in Paramus, NJ

ROLE SUMMARY

The primary role of this position is to contribute to RNA Platform improvements to help advance Pfizer's RNA vaccine programs. The candidate will work closely with the mRNA Platform director to develop and apply interdisciplinary approaches to understand the mechanisms of action of different types of RNA-based viral vaccine drug substance and lipid nanoparticle drug products and participate in the development of next-generation RNA vaccine prototypes.

ROLE RESPONSIBILITIES

• Work closely with the mRNA Platform director to develop mRNA based vaccines
• Design mRNA genetic/structural elements & support the development of novel delivery methods for efficient RNA transfer into target cells for optimum vaccine efficacy
• Conduct cellular and molecular studies (eg. RT-qPCR, FACs, Luminex, Confocal Microscopy-based assays) to understand the mechanisms of action of novel RNA vaccine candidates
• Develop novel tools to visualize and quantify exogenous mRNA and protein interactions in subcellular compartments and in RNA granules with high spatiotemporal resolution, at the single molecule level

BASIC QUALIFICATIONS

The ideal candidate would have some of the following skills and attributes:

• Ph.D. preferably in Immunology, Cell Biology, Biochemistry, Molecular Biology
• 0-3 years relevant industry experience in pre-clinical research and in vaccine technology development
• Hands on experience in mRNA synthesis, purification, characterization, and translational profiling
• Strong understanding of RNA biology and modeling for RNA folding and RNA-protein interactions
• Hands on experience with cell culture and cell-based assays including confocal microscopy-based single molecule assays to characterize RNA-based products
• Strong abilities in scientific analysis, cross-functional collaboration, scientific writing, and public speaking required

PREFERRED QUALIFICATIONS

• Experience in lipid nanoparticle formulation and characterization
• Proficiency in High-Content Imaging using confocal microscopies and associated imaging software
• Proficiency in process development of mRNA-LNP & automation solutions is desired

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• On-site (laboratory-based). Must be able to access or utilize reliable transportation to the Pearl River site
• Experimental designs may occasionally necessitate being on-site early/late or on weekends as needed
• Potential to work with/come in contact with infectious materials

Relocation support available
Work Location Assignment: On Premise

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development