General Laborer, Sr. performs general manual labor tasks including loading, unloading, lifting, digging, and moving materials. Operates a variety of tools to complete assignments according to internal and external policies and regulations. Being a General Laborer, Sr. assembles and disassembles machines, tools, and other work-related equipment. Assists engineers and a variety of other functions with manual labor tasks as needed. Additionally, General Laborer, Sr. may require a high school diploma. Typically reports to a supervisor. The General Laborer, Sr. works under moderate supervision. Gaining or has attained full proficiency in a specific area of discipline. To be a General Laborer, Sr. typically requires 1-3 years of related experience. (Copyright 2024 Salary.com)
General Proximity is a seed-stage startup developing the next generation of induced-proximity medicines. Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.
We are seeking first-rate lead discovery scientists to help us pioneer this uncharted frontier of drug discovery.
A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition[1], but there are many other possible perturbation types whose potential remains unrealized.
General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).
Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[2, 3, 4], and our technology holds the same promise.
We are seeking an experienced Lead Discovery Scientist to be a member of our Platform/Drug Discovery Team. In this position, you will work in close conjunction with our Biology Team in the development of our core drug discovery technology and the generation of a completely novel class of therapeutics.
Your responsibilities will include leading the design and execution of lead discovery campaigns to identify novel small molecule hits and advance them through hit-to-lead and lead optimization stages, working with the Platform and Biology teams to develop and implement biochemical and cell-based assays for hit identification and lead optimization, evaluating compound potency, selectivity, and mechanism of action, biophysical and biochemical assay development, and expressing, purifying, and characterizing target proteins for structural studies.
High Agency. Initiative, independence, and self-accountability are some of our most valued traits.
Enthusiastic. We love people who are excited about what they are doing and are generally attempting to build a high-energy team.
Intensity and Grit. Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.
Prosocial. We are here to create life-saving medicines for the patients who need it most. You should be, too.
Work Hard/Play Hard. We believe time is our most valuable commodity, so we strive to create a culture that reflects this. We won’t drag you through unnecessary meetings or email you at 7 PM on a Saturday. When we're at work, we're there to get things done, and when we're off, we're really off. 🌴
Strong Communication. We like well-written documents over PowerPoints, OKRs over vague mission statements, and weekly one-on-ones over yearly reviews.
Writing First. We have a "writing-first" culture. We believe that clarity of writing reflects clarity of thinking and that the benefits of well-written documentation in a scientific environment are innumerable: democratization of ideation and decision-making, increased reproducibility, quicker scaling and onboarding, and better company-wide alignment, to name a few.
Growth. As an early-stage startup, we value scientists with an independent, can-do attitude. The more hats you can wear, the better. Our job as employers is to put you in positive feedback loops so you can grow in the direction of your choosing.
Title and compensation commensurate with experience. Applications from candidates of diverse backgrounds, women, and members of underrepresented minority groups are particularly welcomed. We look forward to hearing from you. :)
More info at jobs.generalproximity.bio
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