Postdoctorate Scientist jobs in Minnesota

Description:

The Sr .Scientist/Scientist Cell Sourcing will lead the development (Sr. Scientist), implementation, and refinement of robust protocols for the isolation and expansion of primary liver and kidney cells. This role, and team, will be tasked with developing large scale, GMP level protocols to supply cells for R&D cellularization efforts in decellularized liver and kidney scaffolds, and with providing necessary data and documentation support for the preparation of regulatory filings.

- Coordinate with R&D and manufacturing teams to generate technical plans to develop and optimize targeted primary cell isolation protocols from human liver and kidney tissue

- Draft protocols, experimental documentation strategies, summaries, and reports

- Participate in drafting of documentation for regulatory submissions

- Work with a team on a flexible schedule, according to organ availability, to conduct primary cell isolation protocols

- Design and execute experiments to develop methods for downstream purification and expansion of primary liver and kidney cells

- Work with manufacturing and engineering teams to design methods of control for the generation of reliable primary cell manufacturing processes that will adhere to GMP standards

- Perform characterization of cells obtained from isolation and expansion protocols using standard techniques such as flow cytometry and IHC

- Assist in coordination and training activities for tech transfer of fully developed protocols to manufacturing teams

- Communicate using both oral presentations and written documents to broad level of audiences including R&D teams, quality, manufacturing, and upper management

- Contribute to efforts to understand, explore, and incorporate new technologies to advance programs

- Author and submit manuscripts, grants, and abstracts with approval of senior management

Normal week - 50% lab work / 50% desk based work. Needs to be able to adjust and be flexible with this.

Additional Skills & Qualifications:

Doctor of Philosophy (PhD) in Tissue Engineering, Biomedical Engineering, Biological Sciences, or related field

2 (associate) 5 (senior) years of relevant experience working with primary mammalian cell isolation and culture

1 years of relevant industry experience working in a quality-controlled research environment

Experience with primary cell isolations (required Sr

Background knowledge of liver and/or kidney function and experience working with cells from these organs (required Sr

Experience working with human tissue

Background knowledge of perfusion control and fluid flow dynamics

Experience with cell purification techniques such as MACS sorting or size exclusion

Experience with flow cytometry

Experience with immunohistochemistry or immunofluorescence staining

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